Temperature-Humidity Chambers

Temperature-humidity chambers refer to specially designed pieces of equipment used in stability testing to test how well a product or material retains its quality over its lifetime. This equipment provides a trusted and reliable way to conduct stability testing on biological items, industrial products, materials and pharmaceutical products.

These chambers can be used to simulate the exposure of a number of different environmental conditions on products and materials. Some of these environmental conditions include:

• Extreme temperatures

• Sudden and extreme temperature variations

• Moisture or relative humidity

• Electro-dynamic vibrations

• Electromagnetic radiation

• Salt spray

• Rain

• Weathering

• Exposure to sun (causing UV degradation)

When selecting a temperature-humidity chamber, it is essential to thoroughly research what is available in the market based and select the best one based on the needs of each individual project.

Testing Humidity with Chambers:

Temperature-humidity chambers are able to simulate a variety of different weather conditions. In the following section of the article, we will explore how they can be used to test what effect humidity would have on a particular product.

Step 1:

Pierce a humidity capsule and place it in the chamber to create the required levels of humidity. Humidity capsules can be used to produce levels of relative humidity in the range of 0-95%, increasing at 5% increments. The particular humidity capsule should be chosen based on the aims of each particular test.

Step 2:

Place the test sample in a separate section of the chamber.

Step 3:

Place a sensor cap to on top of the unit to tightly seal the temperature-humidity chamber. This will allow you to measure the level of humidity within the unit for the duration of the test.

Step 4:

Affix a logger cap onto the base of the chamber. The logger cap can be connected to any laptop or computer via a USB cable or a wireless connection. If your test is being performed outside of wireless range, you can use aerials and cabling to broadcast the signal of your unit.

Step 5:

Incubate tests at the required temperature. When the tests are complete dispose of the temperature-humidity chamber. Using a temperature-humidity chamber to conduct stability testing can result in a number of practical benefits such as:

• Act as suitable environmental chambers

• Each test is monitored in its own micro-humidity chamber

• You can select from a full range of temperature, weather and humidity conditions

• Allow you to continuously collect data throughout the study for each test

• Chambers assist with lowering cross contamination and improving sample integrity

• The sensors of each chamber can be easily calibrated

• Eliminate the need for alt solutions or desiccators

• Units are easy to set-up

• Units are ideal for working with toxic materials

• The system can be used for monitoring and mapping applications

• Data can be automatically backed up throughout the project.

Temperature-Humidity Chambers from Amebis Ltd. Pharmeceutical testing specialists in the US and Europe.

http://www.amebisltd.com/

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Temperature-Humidity Sensors in Pharmaceutical Testing

Pharmaceutical Products fall under some of the most stringent regulations of any manufactured good out there. Product testing against varying environmental conditions need to be recorded using both accurate temperature-humidity sensors and reliable data logging software.

Such process control testing is referred to as stability testing because test materials are analysed for any degradation or significant physical changes throughout various temperature and relative humidity settings.

The stability of a pharmaceutical product is a measure of its ability to resist deterioration during the period within which its properties and characteristics can be expected to remain with certain limits. All articles intended for use in diagnosis, mitigation, treatment of prevention of disease undergo some form of testing, often multiple times in the product development cycle, from drug development to package selection. ?

Temperature-humidity sensors are just one portion of a stability testing system. Older more cumbersome systems make use of large environmental chambers to contain all the test samples. The disadvantages of environmental chambers are that you can only test the samples for one temperature and relative humidity setting in equipment that takes up a lot space and has high running costs. Modern bench-top stability testing units or "small scale stability testing units" allow for many different sensor readings to be logged at the same time in a relatively small amount of physical space. ?

Calibration requirements for temperature-humidity sensors ?

Generally speaking temperature sensors require less calibration as they tend to maintain better accuracy levels. The humidity sensor will require more frequent calibration as accuracy can shift at higher temperature ranges. This is not a substantial problem if the product in question needs to be tested for relatively low temperature ranges but is the control process requires cycling over a large temperature range then a robust temperature-humidity sensors with frequent calibrations is recommended.?

When purchasing new and used units it is also advisable to ensure that calibration certificates are provided with the purchase (Don't forget to ask if the certificates are traceable and for which regions they are valid). A calibration certificate should be a minimum requirement to conform for international standards. ?

Various international validation requirements also regulate the way electronic signatures are used, how electronic data is stored and other computerized system requirement affecting Stability Testing. So not only must your sensors be compliant but also any associated data storage units. Those interested in further reading would do well to reference the FDA 21 GMP's Eudralex volume 4 requirements.

Their unique temperature-humidity sensor and 21 CFR part II compliant Amebis Control Software provide one of the most flexible solutions available today. http://www.amebisltd.com/temperature-humidity-sensors-pharmaceutical/

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